<link href="//maxcdn.bootstrapcdn.com/bootstrap/4.1.1/css/bootstrap.min.css" rel="stylesheet" id="bootstrap-css"> <script src="//maxcdn.bootstrapcdn.com/bootstrap/4.1.1/js/bootstrap.min.js"></script> <script src="//cdnjs.cloudflare.com/ajax/libs/jquery/3.2.1/jquery.min.js"></script> <!------ Include the above in your HEAD tag ----------> <b>Risk of bias assessment</b><br><br> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>1.</b> Were the ARRIVE guidelines followed?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> <div class="radio"> <label for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3"> Not reported </label> </div> </div> </div><br> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>2.</b> Were the animals randomly assigned to the experimental group?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> <div class="radio"> <label for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3"> Not reported </label> </div> </div> </div> <ul style="list-style-type:NONE"> <!-- Multiple Radios --> <li><div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>2.1</b> If yes, has the method of randomization been reported?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div> </li> </ul> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>3.</b> Was the group assignment concealed to the investigator?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> <div class="radio"> <label for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3"> Not reported </label> </div> </div> </div> <ul style="list-style-type:NONE"> <!-- Textarea --> <div class="form-group"> <label class="col-md-4 control-label" for="textarea"><b>3.1</b> If yes, please quote. (Leave blank if not reported)</label> <div class="col-md-4"> <textarea class="form-control" id="textarea" name="textarea"></textarea> </div> </div> </ul> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>4.</b> Were the animal caretakers and investigators conducting the experiments blinded to the allocation sequence?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> <div class="radio"> <label for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3"> Not reported </label> </div> </div> </div> <br> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>5.</b> Were the investigators blinded to the assessment, measurement or quantifying the experimental outcome?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> <div class="radio"> <label for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3"> Not reported </label> </div> </div> </div><br> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>6.</b> Was a priori sample size calculation performed?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> <div class="radio"> <label for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3"> Not reported </label> </div> </div> </div> <ul style="list-style-type:NONE"> <li><!-- Textarea --> <div class="form-group"> <label class="col-md-4 control-label" for="textarea"><b>6.1</b> If yes, please quote (incl. the method)</label> <div class="col-md-4"> <textarea class="form-control" id="textarea" name="textarea"></textarea> </div> </div> </li></ul> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>7.</b> Were rules for stopping data collection defined in advance?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> <div class="radio"> <label for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3"> Not reported </label> </div> </div> </div><br> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>8.</b> Have any excluded animals been reported?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> <div class="radio"> <label for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3"> Not reported </label> </div> </div> </div> <ul style="list-style-type:NONE"> <!-- Textarea --> <li><div class="form-group"> <label class="col-md-4 control-label" for="textarea"><b>8.1</b> If yes, was attrition reported separately for sex?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div> </li> </ul> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>9.</b> Were definition and handling of outliers defined a priori in the study design/methods section?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> <div class="radio"> <label for="radios-2"> <input type="radio" name="radios" id="radios-2" value="3"> Not reported </label> </div> </div> </div> <br> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>10.</b> Was the funding source reported?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div> <ul style="list-style-type:NONE"> <li> <div class="form-group"> <label class="col-md-4 control-label" for="checkboxes"><b>10.1</b> If yes, categorize the source of funding</label> <div class="col-md-4"> <div class="checkbox"> <label for="checkboxes-0"> <input type="checkbox" name="checkboxes" id="checkboxes-0" value="1"> public funding </label> </div> <div class="checkbox"> <label for="checkboxes-1"> <input type="checkbox" name="checkboxes" id="checkboxes-1" value="2"> industry funding </label> </div> </div> </div> </li> <!-- Textarea --> <li><div class="form-group"> <label class="col-md-4 control-label" for="textarea"><b>10.2 </b> If yes, please extract the name of the funder(s).</label> <div class="col-md-4"> <textarea class="form-control" id="textarea" name="textarea"></textarea> </div> </div> </li> </ul> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>11.</b> Was a conflict of interest reported?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes, conflict of interest was reported </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> Yes, it was reported that no conflict of interest existed </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-2" value="3"> No conflict-of-interest-statement included </label> </div> </div> </div><br> <!-- Multiple Radios --> <div class="form-group"> <label class="col-md-4 control-label" for="radios"><b>12.</b> Was the research project pre-registered?</label> <div class="col-md-4"> <div class="radio"> <label for="radios-0"> <input type="radio" name="radios" id="radios-0" value="1" checked="checked"> Yes </label> </div> <div class="radio"> <label for="radios-1"> <input type="radio" name="radios" id="radios-1" value="2"> No </label> </div> </div> </div>